Longevity Supplements: What’s New and What Works?

Aging is inevitable. But how we age? That’s something we can influence. Thanks to new advances in health science and a deeper understanding of how our bodies work at a cellular level, longevity supplements have moved from the fringes of biohacking forums to mainstream wellness routines. But with so many options out there, which ones actually deliver?

In this article we’ll explore the best longevity supplements backed by science, emerging innovations worth watching, and how to choose the right one for your goals.

The Science of Longevity: Why Supplements Matter

Longevity isn’t just about living longer, it’s about living better, longer. At the core of this concept is cellular health: keeping cells functioning optimally, reducing damage, and promoting regeneration. Many of the best longevity supplements aim to support this by targeting key processes like:

• Autophagy: the body's natural cellular cleanup system
  
  

• Mitochondrial health: the powerhouses of your cells
  
  

• Senescent cell removal: clearing out "zombie" cells
  
  

• Inflammation control: reducing chronic low-grade inflammation

These processes play a critical role in slowing biological aging, supporting energy, and even preventing age-related diseases.

1. Mimio Biomimetic Cell Care

One of the most exciting advancements in the longevity space is Mimio Biomimetic Cell Care. This supplement is designed to replicate the cellular and metabolic benefits of a 36-hour fast, without actually fasting.

What It Does:

Mimio targets autophagy and cellular resilience by mimicking the signaling pathways activated during fasting. That means your body can enter a state of cellular repair and rejuvenation even when you’re not skipping meals. It’s ideal for those who want the benefits of fasting but struggle to maintain strict routines.

Learn more about the science of fasting and longevity: 10 Benefits of 36-Hour Fasting

Key Ingredients:

• Fasting mimetic compounds that promote cellular repair
  
  

• Nutrient blends supporting mitochondrial health and inflammation regulation

Why It Stands Out:

Backed by research from UC Davis and developed through clinical trials, Mimio represents a new generation of biomimetic longevity supplements—designed to work with your biology, not against it.

2. NMN (Nicotinamide Mononucleotide)

A precursor to NAD+, NMN has exploded in popularity thanks to its role in energy metabolism and DNA repair. NAD+ levels decline with age, and restoring them has been linked to improved mitochondrial function and enhanced lifespan in animal models.

Why It Matters: By boosting NAD+, NMN may help support cognitive function, metabolic health, and cellular repair.

Caveat: Human research is still ongoing, and quality varies significantly between brands.

3. Fisetin

A natural flavonoid found in strawberries and apples, fisetin has emerged as a potent senolytic, which is a compound that helps clear out senescent (zombie) cells.

Benefits:

• Reduces inflammation
  
  

• Supports healthy aging by improving tissue function

What the Research Says: Animal studies have shown fisetin to extend lifespan and reduce age-related disease markers. Human trials are in early stages, but promising.³

4. Quercetin + Dasatinib (Senolytic Stack)

This combination is another powerful senolytic protocol. While dasatinib is a prescription drug, the combo is studied for selectively removing dysfunctional cells.

Known Benefits:

• Improved tissue regeneration
  
  

• Reduced markers of inflammation and aging⁴

Important Note: This stack should be approached with caution and under medical supervision. It’s not recommended for casual use without professional oversight.

5. Omega-3 Fatty Acids (EPA/DHA)

You might not think of fish oil as a "longevity hack," but omega-3s have some of the most well-documented benefits for healthy aging.

What They Do:

• Reduce systemic inflammation
  
  

• Improve cardiovascular health
  
  

• Support brain function and memory⁶

Best Sources:

High-quality fish oil supplements, algae oil (for plant-based diets), and fatty fish like salmon or sardines.

6. Curcumin

This anti-inflammatory powerhouse found in turmeric has shown potential in combating age-related diseases from arthritis to cognitive decline.

Why It’s Popular: Curcumin helps suppress NF-kB, a molecule involved in inflammatory responses that increase with age.

Pro Tip: Choose supplements with bioavailability enhancers like black pepper extract (piperine) to improve absorption.

7. Resveratrol

Found in red wine and grapes, resveratrol activates sirtuins—proteins linked to longevity and cellular repair.

What Research Shows:

In animal models, resveratrol has been shown to extend lifespan and improve markers of metabolic health. Human trials are mixed but ongoing.

8. Vitamin D3 + K2

Vitamin D3 is critical for immune function, bone health, and mood regulation. Pairing it with K2 helps ensure calcium gets directed to bones rather than arteries.¹²

Why It Matters for Longevity:

Deficiencies in these vitamins are linked to increased mortality risk, especially in older adults.

9. Creatine: More Than Muscle

Most people associate creatine with bodybuilders, but emerging science is revealing its potential role in healthy aging.⁹

Longevity Benefits:

• Supports brain function: Creatine fuels energy-intensive brain processes and may support memory and cognition in aging adults.
  
  

• Preserves muscle mass: Especially important for healthy agers to prevent sarcopenia (age-related muscle loss).
  
  

• Improves mitochondrial function: Critical for cellular energy and reducing fatigue.

Backed by Research:

Studies show creatine supplementation may support cognitive performance and muscle function in older adults, making it one of the most underappreciated longevity tools.¹⁰

People Also Ask: Fast Longevity Supplement FAQs

What supplement is best for anti-aging?

There’s no single magic pill, but some of the most well-researched anti-aging supplements include NMN (for NAD+ support), fisetin (a natural senolytic), and omega-3s. For those looking for fasting benefits without strict protocols, Mimio Biomimetic Cell Care offers a biomimetic approach to cellular rejuvenation.

Is NAC or NMN better?

NAC (N-acetyl cysteine) helps boost glutathione, a major antioxidant, while NMN boosts NAD+, which is essential for energy and cellular repair. Both offer unique longevity benefits. Many biohackers stack them together, but NMN has more data directly tied to lifespan extension.¹¹

What vitamin adds years to life?

Vitamin D3, especially when combined with K2, has been associated with reduced mortality risk and improved cardiovascular health in numerous studies.¹²

How to Choose the Best Longevity Supplement for You

Not all supplements are created equal. Here’s how to navigate your options:

• Check the science: Look for peer-reviewed studies or clinical trials.
  
  

• Watch the sourcing: Choose brands that prioritize quality and transparency.
  
  

• Be wary of hype: Just because a supplement is trending doesn’t mean it’s effective.
  
  

• Consider your lifestyle: For example, if fasting isn’t feasible, a biomimetic like Mimio can be a powerful ally.
  
  

• Talk to your doctor: Especially when combining supplements or if you have underlying conditions.

Longevity Is a Daily Practice

There’s no magic pill for eternal youth, but there are tools that can support a longer, healthier life. From fasting mimetics like Mimio Biomimetic Cell Care to foundational nutrients like omega-3s and vitamin D, the best longevity supplements help your body do what it was designed to do: thrive.

Whether you're a seasoned biohacker or a curious newcomer, the future of aging well lies not just in what you add to your routine—but in what you activate within yourself.

References

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2. Campisi, J. (2013). Aging, cellular senescence, and cancer. Annual Review of Physiology.
   
   

3. Yousefzadeh, M. J. et al. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine.
   
   

4. Zhu, Y. et al. (2015). The Achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging Cell.
   
   

5. Longo, V. D., & Panda, S. (2016). Fasting, circadian rhythms, and time-restricted feeding. Cell Metabolism.
   
   

6. Belkaid, Y., & Hand, T. W. (2014). Role of the microbiota in immunity and inflammation. Cell.
   
   

7. Irwin, M. R. (2015). Why sleep is important for health. Annual Review of Psychology.
   
   

8. Jequier, E., & Constant, F. (2010). Water as an essential nutrient. European Journal of Clinical Nutrition.
   
   

9. Gualano, B., et al. (2014). Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain. Amino Acids.
   
   

10. Dolan, E., et al. (2020). Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Experimental Gerontology.
    
    

11. Amanat, S., et al. (2021). The antioxidant and anti-inflammatory properties of N-acetylcysteine: Its use in chronic diseases. Biomedicine & Pharmacotherapy.
    
    

Autier, P., et al. (2014). Vitamin D status and ill health: a systematic review. The Lancet Diabetes & Endocrinology.