Dave Asprey: The Key to Longevity & Optimizing Your Metabolism

“Nature has given us a lot of these very interesting regenerative states of the body, regenerative pathways that our body naturally uses to heal ourselves. What we do with Mimeo is take what nature is already doing and recreate it so you can get those same benefits on demand.” — Dr. Chris Rhodes

What If Aging Was Optional?

Dave Asprey, the father of biohacking, has spent decades proving that aging doesn’t have to mean decline. His mission? To help people live longer, healthier, and more energized lives by optimizing metabolism, hacking biology, and leveraging cutting-edge science—including fasting mimetics.

In a recent episode of Dave’s podcast, The Human Upgrade, Asprey sat down with Dr. Chris Rhodes to dive into one of the most powerful levers of longevity: metabolism. “If you want to hack aging, you have to start with metabolism. A well-optimized metabolism isn’t just about burning fat—it’s about energy, cellular repair, and ultimately, how long you live.” — Dave Asprey

So, how do you biohack your metabolism for longevity? Let’s break it down.

Why Metabolism Matters for Longevity

Metabolism isn’t just about how quickly you burn calories—it’s the engine that drives every function in your body. A sluggish metabolism doesn’t just make it harder to maintain weight; it can also lead to fatigue, brain fog, and accelerated aging at the cellular level.

Here’s why metabolic health is essential for longevity:

• Energy Production: A healthy metabolism ensures your cells efficiently convert nutrients into ATP (energy), keeping you sharp and energized.

• Cellular Repair & Regeneration: Optimized metabolism promotes autophagy, the process where cells clean out damaged components and regenerate—key for longevity.

• Inflammation Control: Metabolic dysfunction is linked to chronic inflammation, which accelerates aging and contributes to age-related diseases.

• Fat Burning & Mitochondrial Function: A fast, efficient metabolism supports fat oxidation and strengthens mitochondria—the powerhouses of your cells.

So, what’s the best way to train your metabolism to work for you, instead of against you? Enter fasting and biomimetics.

Fasting & Biomimetics: A Longevity Power Duo

Fasting has long been recognized as a metabolic reset button—activating autophagy, reducing oxidative stress, and improving insulin sensitivity. But let’s be real: fasting can be tough. That’s where fasting mimetics come in.

What Is a Fasting Mimetic?

A fasting mimetic is a compound that mimics the biological benefits of fasting without requiring you to actually fast. This means you can activate cellular repair, optimize metabolism, and enhance longevity—all while still eating.

Dave Asprey & Dr. Chris Rhodes on Fasting Mimetics

Asprey and Dr. Rhodes explored how Mimio is pioneering the field of biomimetic science. Mimio’s formula is designed to replicate the benefits of fasting at the cellular level, activating the same longevity pathways triggered by caloric restriction.

By using biomimetic compounds, you can:

• Trigger autophagy (cellular cleanup mode)

• Boost mitochondrial efficiency (more energy, better metabolism)

• Support longevity genes like AMPK & sirtuins

In short? You get all the fasting benefits—without skipping meals. And for those already well-practiced in fasting? Mimio actually enhances your existing fasting regimens.

Metabolic Optimization: How to Biohack Aging Like Dave Asprey

Asprey’s approach to longevity isn’t just about supplements—it’s about metabolic training. Here are his top strategies for optimizing metabolism and aging smarter:

1. Train Your Body to Burn Fat for Fuel

Your metabolism thrives when it can efficiently switch between glucose and fat for energy (a state called metabolic flexibility). Strategies to improve this include:

• Intermittent fasting (IF): Time-restricted eating windows (like 16:8) encourage fat oxidation.

• Low-carb & keto cycling: Reducing carbs occasionally helps train your metabolism to burn fat.

• Exercise in a fasted state: This enhances fat adaptation and mitochondrial health.

2. Support Your Mitochondria

Mitochondria decline with age, leading to fatigue and slower metabolism. To keep them strong:

• Prioritize quality sleep (mitochondrial repair happens at night), and aim for 8 hours of rest per night

• Get enough magnesium, CoQ10, and NAD+ boosters

• Use fasting mimetics like Mimio to enhance mitochondrial function

3. Reduce Inflammation with Smart Nutrition

Chronic inflammation is a silent metabolism killer. Asprey recommends:

• Avoiding processed seed oils (like canola and soybean oil)

• Eating anti-inflammatory fats (grass-fed butter, olive oil, and omega-3s)

• Eliminating sugar & processed carbs (which spike insulin and cause metabolic dysfunction)

4. Use Fasting Mimetics to Supercharge Longevity

Fasting mimetics like Mimio mimic the metabolic benefits of fasting without extreme caloric restriction. This means:

• Better blood sugar control

• Increased fat oxidation

• Enhanced cellular repair & longevity activation

It’s metabolic biohacking—without the struggle.

Why Mimio Is a Game-Changer for Metabolic Health

Dave Asprey has always been at the forefront of longevity science, and in his conversation with Dr. Chris Rhodes, it’s clear that fasting mimetics are the next evolution in metabolic optimization.

Mimio is scientifically designed to mimic the body’s natural fasting response—helping you activate the same pathways without skipping meals. This means:

• More energy & focus (without fasting-induced brain fog)

• Better metabolic flexibility (burn fat efficiently)

• Support for longevity pathways (AMPK, autophagy, & sirtuins)

If you’re serious about biohacking aging, it’s time to upgrade your metabolism.

Start Your Mimio Journey Today

The Future of Metabolic Longevity

Dave Asprey’s approach to longevity is clear: optimize metabolism, support mitochondrial health, and leverage cutting-edge science like fasting mimetics. Whether through fasting, targeted nutrition, or biomimetic supplementation, the goal is the same—train your body to age better.

If you’re ready to take control of your metabolism and longevity, now’s the time to act.

🎧 Listen to The Human Upgrade episode with Dave Asprey & Dr. Chris Rhodes
🔗Experience the benefits of Mimio here

Because aging should be optional—and your metabolism holds the key.